What is GeneProb and How Does It Work?
GeneProb is a tool that uses DNA test results and pedigree information to estimate the likelihood that an untested animal carries a particular gene or genetic condition. Rather than requiring every animal to be DNA tested, GeneProb applies the principles of inheritance to calculate carrier probabilities for related animals within a pedigree. GeneProb calculations are updated weekly as new DNA test results become available, improving the accuracy of carrier risk estimates throughout the pedigree.
The Australian Wagyu Association (AWA) currently provides GeneProb analysis for the following recognised genetic conditions in Wagyu cattle:
- Spherocystosis (B3)
- Chediak Higashi Syndrome (CHS)
- Factor XI Deficiency (F11)
- IARS Disorder (IARS)
- Annexin A10 (ANXN10)
- Claudin 16 Deficiency (CL16)
Benefits of GeneProb
GeneProb provides several important benefits for breeders:
- Reduces unnecessary DNA testing: By identifying animals with a higher probability of carrying a genetic condition, GeneProb helps breeders focus testing efforts where they will have the greatest value, reducing both unnecessary testing and associated costs.
- Supports informed breeding decisions: Helps breeders better understand genetic risk within their herd and make informed mating decisions that minimise the likelihood of producing affected offspring.
- Makes the most of existing DNA information: DNA test results from one animal can provide valuable information for related animals throughout the pedigree, maximising the value of genetic testing.
- Assists with genetic condition management: Enables breeders and the AWA to monitor the prevalence of known genetic conditions and make informed decisions to manage their spread within the population.
- Maintains breeding progress: Allows breeders to manage genetic conditions without unnecessarily removing animals with valuable genetics from their breeding program.
Viewing GeneProb Results
GeneProb results can be viewed through Member Login in Helical and on the Public Animal Database.
Member log in
In the Animals tab on Helical, members can change their view between the following to see their GeneProb results:
- General Animal Information
- Genetic Conditions Probabilities and Test Requests
Public Database
Users of the public database can select filters for Genetic Conditions when searching.
Users can then select an individual animal to view its details, including any available Genetic Condition test and GeneProb results as seen below. This animal shows a 25% chance of being an ANXN10 carrier.
The table below outlines the result codes.
Important to Remember
GeneProb provides an estimated probability based on available pedigree and DNA information; it is not a definitive test result. Direct DNA testing remains the only way to determine an animal’s exact genetic status. GeneProb should therefore be used as a decision-support tool to help identify animals that may benefit from further testing.